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2014

Dr D Blackhurst
Low-alcohol wine and the health benefits uncorked.
Wineland February 2014.

Macharia M, Kengne A.P, Blackhurst D. M, Erasmus R.T, Hoffmann M, and Matsha T. E.
Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans.
Hindawi Publishing Corporation
Oxidative Medicine and Cellular Longevity, Volume 2014, Article ID 135650, 10 pgs. (on line)

Bohm M, Henderson H, van der Zwan H, Basson S.  
L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier’,
Journal of the South African Veterinary Association 2014; 85(1), 1042, 5 pages.

Moodley A, Bhola S, Omar F, Mogambery
Antiretroviral therapy-induced Leber’s hereditary optic neuropathy.
SAJHIV 2014; 15, (2) 69-71.

Caire-Brandli I, Papadopoulos A, Malaga W, Marais D, Canaan S, Thilo L, de Chastellier C.
Reversible Lipid Accumulation and Associated Division Arrest of Mycobacterium avium in Lipoprotein-Induced Foamy Macrophages May Resemble Key Events during Latency and Reactivation of Tuberculosis.
Infection & Immunity 2014; 82 (2), 476-490.

Macharia M, Kengne A.P, Blackhurst D. M, Erasmus R. T.
The impact of chronic untreated hyperglycaemia on the long-term stability of paraoxonase 1 (PON1) and antioxidant status in human sera.
J Clin Pathol 2014; 67, 55-59.

Rebe K.B, de Swart G, Berman P.A, Struthers H, McIntyre J.A.
Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with men.
SAMJ 2014; 104, (1), 49-51.

Marais A.D, Solomon G.A.E, Blom D.J.
Dysbetalipoproteinaemia: A mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E.
Critical Reviews in Clinical Laboratory Sciences 2014; (online) pg 1-17.

Lambert G, Petrides F, Chatelais M, Blom D.J, Choque B, Tabet F, Wong G, Rye K.A, Hooper A, Burnett J. R, Barter P.J, Marais D.
Elevated Plasma PCSK9 Level Is Equally Detrimental for Patients With Nonfamilial Hypercholestrolemia and Heterozygous Familial Hypercholesterolemia, Irrespective of Low-Density Lipoprotein Receptor Defects.
Journal of American College of Cardiology 2014; 63 (22), 2366-2373.

Ross IL, Marais AD.
The influence of glucocorticoids on lipid and lipoprotein metabolism and atherosclerosis.
S Afr Med Journal 2014:104(10):671-674.

Parihar SP, Guler R, Khutlang R, Lang DM, Hurdayal R, Mhlanga MM, Suzuki H, Marais AD, Brombacher F.
Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation.
Journal of Infectious Disease 2014;209:754-763.

Nduhirabandi F, Huisamen B, Strijdom H, Blackhurst D, Lochner A.
Short-term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity.
Journal of Pineal Research 2014; 57:317-332.

Owen EP, Nandhlal J, Leisegang F, van der Watt G, Nourse P, Gajjar P.
Common mutation causes cystosis in the majority of black South African patients.
Pediatr Nephrol. 2014 Oct 18. [Epub ahead of print]

Macharia M, Kengne AP, Blackhurst DM, Erasmus RT, Matsha TE. Paraoxonase1 Genetic Polymorphisms in Mixed Ancestry African Population.
Mediators Inflamm. 2014;2014:217019. doi: 10.1155/2014/217019. Epub 2014 Nov 16.,

 

2013

Wan Iryani W. Ismail, Judy A King, Khawar Anwar and Tahir S. Pillay.
Indinavir and Nelfinavir Inhibit Proximal Insulin Receptor Signaling and Salicylate Abrogates Inhibition: Potential Role of NFkappa B Pathway.
Journal of Cellular Biochemistry 9999:1-10 (2013)

Retsilisitoe R Moholisa, Rayner Brian R, Owen E Patricia, Schwager Sylva LU, Stark Joalice S, Badri Motassim, Cupido Clint L, Sturrock Edward D.
Association of B2 Receptor Polymorphisms and ACE activity with ACE Inhibitor-Induced Angioedema in Black and Mixed Race South Africans.
Journal of Clinical Hypertension. 2013 Jun;15(6):413-9.

Marais AD.
Dietary lipid modification for mild and severe dyslipidaemias.
Proceedings of the Nutrition Society. 2013, 72, 337–341

Blom DJ, Marais AD, Raal FJ, Lambert G.
The potential use of monoclonal antibodies and other novel agents as drugs to lower LDL cholesterol.
Clin Lipidology 2013 (2)

Marais AD, Blom DJ.
Recent advances in the treatment of homozygous familial hypercholesterolaemia.
Curr Opinion Lipidology 2013,24:288-294.

Jones S.W Erika, Owen EP, Rayner BL.
The association of the R563Q Genotype of the ENaC with Phenotypic Variation in Southern Africa.
American Journal of Hypertension, 25:12,1286-1291.

Haarburger D, Renison R, Meldau S, Eastman R, Van der Watt G.
Teenaged siblings with progressive neurocognitive disease.
Clinical Chemistry 59:8, 1160-1165 (2013).

Van der Watt G.
Investigation of metabolic encephalopathy.
CME Jan 2013, vol 31.No1.

Macharia M, Kengne AP, Blackhurst DM, Erasmus RT, Matsha TE.
The impact of hyperglycaemia on the long-term stability of antioxidant status in human sera.
JCP 2013

Cuchel M, Meagher EA, Theron du toit H, Blom D, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plesis Anna ME, Propert KJ, Sasiela WJ, Bloeden LT, Rader JD.
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
The Lancet, 381:40-46.

Singaraja RR, Sivapalaratnam S, Hovingh K, Dube M, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, Tietjen I, Wong K, Mitnaul LJ, van Heek M, Lin L, Roddy TA, McEwan J, Dallinge-Thie G, van der Zee L, Verwoert G, Winther M, Van Duijn C, Hofman A, Trip MD, Marais AD, Asztalos B, Landmesser U, Sijbrands E, Kastelein JJ, Hayden MR.
The impact of Partial and Complete Loss-of-function Mutations in Endothelial Lipase on High-Density Lipoprotein levels and Functionality in Humans.
Cardiovascular Genetics; 6:54-62.

 

2012

Barbara Huisamen, Daneel Dietrich, Nicole Bezuidenhout, John Lopes, Brian Flepisi, Dee Blackhurst, Amanda Lochner.
Early cardiovascular changes occurring in diet-induced, obese insulin-resistant rats.
Mol Cell Biochem (2012) 368:37–45

Macharia M, Hassan MS, Blackhurst DM, Erasmus RT, Matsha TE.
The growing importance of PON1 in cardiovascular health: a review.
Journal of Cardiovascular Medicine, 2012, volume 13(7), 443-453.

V Davids, DM Blackhurst, AA Katz, EH Harley.
Origins and function of 3-ribosylurate in bovid erythrocytes.
The Veterinary Journal, 2012, volume 192, 326-332.

Lamont K, Blackhurst D, Albertyn Z, Marais D, Lecour S.
Lowering the alcohol content of red wine does not alter its cardioprotective properties.
SAMJ, 2012, volume 102(6), 565-567.

Klug EQ, Raal FJ, Marais AD, Taskinen M-R, Dalby AJ, Schamroth C, Rapeport N, Jankelow D, Blom DJ, Catsicas R, Webb DA.
South African dyslipidaemia guideline consensus statement.
SA Heart 2012;9(2):106-117.

Fierdoz Omar
Essential laboratory knowledge for the clinician.
CME July 2012, Vol 30, 7:244-248

Karen Sliwa, Jasmine G Lyons, Melinda J Carrington, Sandrine Lecour, David Marais, Frederick j Raal, Simon Stewart.
Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of the de novo presentations of heart disease.
Cardiovascular Journal of Africa, 2012, Vol 23, No7: 389-395.

EP Owen, F Leisegang, A Whitelaw, J Simpson, S Baker, R Wurzner, P Potter, A Orren.
Complement component C5 and C6 mutation screening indicated in meningococcal disease in South Africa.
S Afri Medical J 2012;102 (6):525-527.

L Bohm, AM Serafin, P Fernandez, G van der Watt, PJD Bouic, J Harvey.
Plasma Sarcosin does not distinguish early and advanced stages of prostate cancer.
S Afri Medical J 2012;102 (8):677-679.

Adrian Stephen Wolferstan Tordiff, George van der Watt, Fred Reyers.
Cystine urolithiasis in a caracal (caracal caracal).
Journal of Zoo and Wildlife Medicine 2012; 43(3): 649-651.

Marais AD, Blom DJ, Petrides F, Goueffic Y and Lambert G.
Proprotein convertase subtilisin/kexin type 9 inhibition.
Curr Opin Lipidol 2012.

 

2011

Fortgens P, Pillay TS.
Pseudohyponatremia revisited: a modern-day pitfall.
Arch Pathol Lab Med. 2011 Apr;135(4):516-9.

Haarburger D, Pillay TS.
Historical perspectives in diagnostic clinical pathology: development of the pregnancy test.
J Clin Pathol. 2011 Jun;64(6):546-8. Epub 2011 Apr 2.

Clausen JD, McIntosh DB, Woolley DG, Andersen JP.
Modulatory ATP binding affinity in intermediate states of E2P dephosphorylation of sarcoplasmic reticulum Ca2+-ATPase.
J Biol Chem. 2011 Apr 1;286(13):11792-802. Epub 2011 Feb 2.

Blakemore R, Nabeta P, Davidow AL, VAdwai V, Tahirli R, Munsamy V, Nicol M, Jones M, Persing DH, Hillen Ruesch-Gerdes S, Leisegang F, Zamudio C, Rodrigues C, Boehme CC, Perkins MD, Alland D.
A multi-Site Assessment of the Quantitative Capabilities of the Xpert ® MTB Assay. 
Am J Respir Crit Care Med. 2011 Nov 1;184(9):1076-84.

A Orren, EP Owen, HE Henderson, L van der Merwe, F Leisegang, C Stassen, and PC Potter.
Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitides infections and analysis of the frequencies of C6Q0 gene defects in South Africans.
Clinical & Experimental Immunology 2011;167 :459-471.

 

2010

Gammon DW, Steenkamp DJ, Mavumengwana V, Marakalala MJ, Mudzunga TT, Hunter R, Munyololo M.
Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol.
Bioorg Med Chem. 2010 Apr 1;18(7):2501-14.

Stanfliet JS, King JA, Pillay TS 
Pathology request guidelines: Haematology questioned. 
S Afr Med J. 2010 May 4;100(5):262-264

Haarburger D, Pillay TS
Discovery proteomics: application to HIV infection.
J Clin Pathol. 2010;63:285-287

Omar F, van der Watt G, November V, Pillay TS.
Plasma free fatty acid reference interval in South African neonates in the first week of life.
Ann Clin Biochem. 2010 Jul;47(Pt 4):381-382

van der Watt G, Owen EP, Berman P, Meldau S, Watermeyer N, Olpin SE, Manning NJ, Baumgarten I, Leisegang F, Henderson H.
Glutaric aciduria type 1 in South Africa-high incidence of glutaryl-CoA dehydrogenase deficiency in black South Africans.
Mol Genet Metab. 2010 Oct-Nov;101(2-3):178-82.

Samia P, Wieselthaler N, van der Watt GF, Wilmshurst JM.
Hemiatrophy of the spinal cord in a patient with mucopolysaccharidosis type IIIB.
J Child Neurol. 2010 Oct;25(10):1288-91.

Van der Watt GF, Eley B, Henderson H.
Whole blood mitochondrial DNA depletion in South African HIV-infected children.
Journal of Paed Biochem. 2010; in press.

Jones ESW, Owen EP, Davidson JS, van der Merwe L, Rayner Bl.
The R563Q Mutation of the Epithelial sodium channel beta subunit is associated with Hypertension. 
CardioVascular Journal of Africa 2011 Sep-Oct;22(5):241-4

Joska JA, Combrinck M, Valcour VG, Hoare J, Leisegang F, Mahne AC, Myer L, Stein DJ.
Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa.
J Neurovirol. 2010 Oct;16(5):377-83.

Wilmshurst JM, Lillis S, Zhou H, Pillay K, Henderson H, Kress W, Müller CR, Ndondo A, Cloke V, Cullup T, Bertini E, Boennemann C, Straub V, Quinlivan R, Dowling JJ, Al-Sarraj S, Treves S, Abbs S, Manzur AY, Sewry CA, Muntoni F, Jungbluth H.
RYR1 mutations are a common cause of congenital myopathies with central nuclei.
Ann Neurol. 2010 Nov;68(5):717-26.

Naidoo R, Ungerer L, Cooper M, Pienaar S, Eley BS.
Primary immunodeficiencies: a 27-year review at a tertiary paediatric hospital in Cape Town, South Africa.
J Clin Immunol. 2011 Feb;31(1):99-105. Epub 2010 Sep 22.